Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment
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N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment
N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and inflammation. Moreover, DMA enhances bone regeneration in vivo. Therefore, our in vivo and in vitro...
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Epigenetic mechnisms are essential for normal development and alterations of epigenetic processe are correlated with many human diseases, e.g., cancer. One of the important epigenetic modifications, acetylation of lysine, is mainly recognized by structurally conserved protein module bromodomains. Targeting bromodomains by small molecules is an emerging therapeutic strategy for cancer treatment....
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